Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.
Identifieur interne : 000593 ( Main/Exploration ); précédent : 000592; suivant : 000594Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.
Auteurs : Alex J. Thompson [Royaume-Uni] ; Michael Hughes [Royaume-Uni] ; Salzitsa Anastasova [Royaume-Uni] ; Laurie S. Conklin [États-Unis] ; Tudor Thomas [Royaume-Uni] ; Cadman Leggett [États-Unis] ; William A. Faubion [États-Unis] ; Thomas J. Miller [États-Unis] ; Peter Delaney [Australie] ; François Lacombe [France] ; Sacha Loiseau [France] ; Alexander Meining [Allemagne] ; Rebecca Richards-Kortum [États-Unis] ; Guillermo J. Tearney [États-Unis] ; Paul Kelly [Royaume-Uni] ; Guang-Zhong Yang [Royaume-Uni]Source :
- Nature reviews. Gastroenterology & hepatology [ 1759-5053 ] ; 2017.
Abstract
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.
DOI: 10.1038/nrgastro.2017.147
PubMed: 29139480
Affiliations:
- Allemagne, Australie, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Île-de-France
- Londres, Paris
- Université de Londres
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Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Hughes, Michael" sort="Hughes, Michael" uniqKey="Hughes M" first="Michael" last="Hughes">Michael Hughes</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Anastasova, Salzitsa" sort="Anastasova, Salzitsa" uniqKey="Anastasova S" first="Salzitsa" last="Anastasova">Salzitsa Anastasova</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Conklin, Laurie S" sort="Conklin, Laurie S" uniqKey="Conklin L" first="Laurie S" last="Conklin">Laurie S. 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Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Hughes, Michael" sort="Hughes, Michael" uniqKey="Hughes M" first="Michael" last="Hughes">Michael Hughes</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Anastasova, Salzitsa" sort="Anastasova, Salzitsa" uniqKey="Anastasova S" first="Salzitsa" last="Anastasova">Salzitsa Anastasova</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Conklin, Laurie S" sort="Conklin, Laurie S" uniqKey="Conklin L" first="Laurie S" last="Conklin">Laurie S. Conklin</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology, Hepatology, and Nutrition, Children's National Health Systems, 111 Michigan Avenue, NW, Washington District of Columbia 20010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Hepatology, and Nutrition, Children's National Health Systems, 111 Michigan Avenue, NW, Washington District of Columbia 20010</wicri:regionArea><wicri:noRegion>Washington District of Columbia 20010</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Tudor" sort="Thomas, Tudor" uniqKey="Thomas T" first="Tudor" last="Thomas">Tudor Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Olympus Surgical Technologies Europe, Fortran Road, Cardiff, CF3 0LT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Olympus Surgical Technologies Europe, Fortran Road, Cardiff, CF3 0LT</wicri:regionArea><wicri:noRegion>CF3 0LT</wicri:noRegion></affiliation></author><author><name sortKey="Leggett, Cadman" sort="Leggett, Cadman" uniqKey="Leggett C" first="Cadman" last="Leggett">Cadman Leggett</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Faubion, William A" sort="Faubion, William A" uniqKey="Faubion W" first="William A" last="Faubion">William A. Faubion</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Thomas J" sort="Miller, Thomas J" uniqKey="Miller T" first="Thomas J" last="Miller">Thomas J. Miller</name><affiliation wicri:level="1"><nlm:affiliation>GreyBird Ventures, 31 Pond View Lane, Concord, Massachusetts 01742, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GreyBird Ventures, 31 Pond View Lane, Concord, Massachusetts 01742</wicri:regionArea><wicri:noRegion>Massachusetts 01742</wicri:noRegion></affiliation></author><author><name sortKey="Delaney, Peter" sort="Delaney, Peter" uniqKey="Delaney P" first="Peter" last="Delaney">Peter Delaney</name><affiliation wicri:level="1"><nlm:affiliation>OptiScan, 16 Miles Street, Mulgrave, Victoria 3170, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>OptiScan, 16 Miles Street, Mulgrave, Victoria 3170</wicri:regionArea><wicri:noRegion>Victoria 3170</wicri:noRegion></affiliation></author><author><name sortKey="Lacombe, Francois" sort="Lacombe, Francois" uniqKey="Lacombe F" first="François" last="Lacombe">François Lacombe</name><affiliation wicri:level="1"><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris</wicri:regionArea><wicri:noRegion>75010 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Loiseau, Sacha" sort="Loiseau, Sacha" uniqKey="Loiseau S" first="Sacha" last="Loiseau">Sacha Loiseau</name><affiliation wicri:level="1"><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris</wicri:regionArea><wicri:noRegion>75010 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Meining, Alexander" sort="Meining, Alexander" uniqKey="Meining A" first="Alexander" last="Meining">Alexander Meining</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm</wicri:regionArea><wicri:noRegion>89081 Ulm</wicri:noRegion><wicri:noRegion>89081 Ulm</wicri:noRegion><wicri:noRegion>89081 Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Richards Kortum, Rebecca" sort="Richards Kortum, Rebecca" uniqKey="Richards Kortum R" first="Rebecca" last="Richards-Kortum">Rebecca Richards-Kortum</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioengineering, Rice University, 6500 Main Street, Suite 1030, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, Rice University, 6500 Main Street, Suite 1030, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Tearney, Guillermo J" sort="Tearney, Guillermo J" uniqKey="Tearney G" first="Guillermo J" last="Tearney">Guillermo J. Tearney</name><affiliation wicri:level="1"><nlm:affiliation>Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Paul" sort="Kelly, Paul" uniqKey="Kelly P" first="Paul" last="Kelly">Paul Kelly</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E1 2AT</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yang, Guang Zhong" sort="Yang, Guang Zhong" uniqKey="Yang G" first="Guang-Zhong" last="Yang">Guang-Zhong Yang</name><affiliation wicri:level="1"><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Gastroenterology & hepatology</title><idno type="eISSN">1759-5053</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Thompson, Alex J" sort="Thompson, Alex J" uniqKey="Thompson A" first="Alex J" last="Thompson">Alex J. Thompson</name></noRegion><name sortKey="Anastasova, Salzitsa" sort="Anastasova, Salzitsa" uniqKey="Anastasova S" first="Salzitsa" last="Anastasova">Salzitsa Anastasova</name><name sortKey="Hughes, Michael" sort="Hughes, Michael" uniqKey="Hughes M" first="Michael" last="Hughes">Michael Hughes</name><name sortKey="Kelly, Paul" sort="Kelly, Paul" uniqKey="Kelly P" first="Paul" last="Kelly">Paul Kelly</name><name sortKey="Thomas, Tudor" sort="Thomas, Tudor" uniqKey="Thomas T" first="Tudor" last="Thomas">Tudor Thomas</name><name sortKey="Yang, Guang Zhong" sort="Yang, Guang Zhong" uniqKey="Yang G" first="Guang-Zhong" last="Yang">Guang-Zhong Yang</name></country><country name="États-Unis"><noRegion><name sortKey="Conklin, Laurie S" sort="Conklin, Laurie S" uniqKey="Conklin L" first="Laurie S" last="Conklin">Laurie S. Conklin</name></noRegion><name sortKey="Faubion, William A" sort="Faubion, William A" uniqKey="Faubion W" first="William A" last="Faubion">William A. Faubion</name><name sortKey="Leggett, Cadman" sort="Leggett, Cadman" uniqKey="Leggett C" first="Cadman" last="Leggett">Cadman Leggett</name><name sortKey="Miller, Thomas J" sort="Miller, Thomas J" uniqKey="Miller T" first="Thomas J" last="Miller">Thomas J. Miller</name><name sortKey="Richards Kortum, Rebecca" sort="Richards Kortum, Rebecca" uniqKey="Richards Kortum R" first="Rebecca" last="Richards-Kortum">Rebecca Richards-Kortum</name><name sortKey="Tearney, Guillermo J" sort="Tearney, Guillermo J" uniqKey="Tearney G" first="Guillermo J" last="Tearney">Guillermo J. Tearney</name></country><country name="Australie"><noRegion><name sortKey="Delaney, Peter" sort="Delaney, Peter" uniqKey="Delaney P" first="Peter" last="Delaney">Peter Delaney</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Lacombe, Francois" sort="Lacombe, Francois" uniqKey="Lacombe F" first="François" last="Lacombe">François Lacombe</name></region><name sortKey="Loiseau, Sacha" sort="Loiseau, Sacha" uniqKey="Loiseau S" first="Sacha" last="Loiseau">Sacha Loiseau</name></country><country name="Allemagne"><noRegion><name sortKey="Meining, Alexander" sort="Meining, Alexander" uniqKey="Meining A" first="Alexander" last="Meining">Alexander Meining</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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